Abstract
A series of 2-phenyl-4-(aminomethyl)imidazoles were designed as conformationally restricted analogs of the dopamine D2 selective benzamide antipsychotics. The title compounds were synthesized and tested for blockade of [3H]YM-09151 binding in cloned African green monkey dopamine D2 receptor preparations. The binding affinity data thus obtained were compared against that of the benzamides and a previously described series of 2-phenyl-5-(aminomethyl)-pyrroles.
MeSH terms
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Animals
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Antipsychotic Agents / chemical synthesis
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Antipsychotic Agents / metabolism
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Antipsychotic Agents / pharmacology*
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CHO Cells
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Chlorocebus aethiops
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Cloning, Molecular
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Cricetinae
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DNA, Complementary
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Imidazoles / chemical synthesis
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Imidazoles / chemistry
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Imidazoles / metabolism
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Imidazoles / pharmacology*
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Protein Binding
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Receptors, Dopamine D2 / drug effects*
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Receptors, Dopamine D2 / genetics
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Receptors, Dopamine D2 / metabolism
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Structure-Activity Relationship
Substances
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Antipsychotic Agents
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DNA, Complementary
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Imidazoles
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Receptors, Dopamine D2