Abstract
It is difficult to predict the clinical activity of antibiotics solely on the basis of in vitro data. Experimental models measuring the relationship between serum concentration and in vivo activity are essential for comparing the activity of different compounds currently available. The critical serum concentration can be used to compare the intrinsic activity of antibiotics on a given bacterial strain. When compared with the minimal inhibiting concentration measured in vitro, "activity loss" can be determined for each antibiotic placed in contact with bacteria in an infected tissue. The relevance of this therapeutic tool in comparison with other methods is discussed.
Publication types
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Comparative Study
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Editorial
MeSH terms
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Animals
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Ceftazidime / administration & dosage
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Ceftazidime / blood*
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Ceftazidime / therapeutic use
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Ciprofloxacin / administration & dosage
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Ciprofloxacin / blood*
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Ciprofloxacin / therapeutic use
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Dose-Response Relationship, Drug
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Drug Evaluation
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Endocarditis, Bacterial / blood*
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Endocarditis, Bacterial / drug therapy
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Endocarditis, Bacterial / microbiology
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Infusions, Intravenous
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Pefloxacin / administration & dosage
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Pefloxacin / blood*
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Pefloxacin / therapeutic use
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Pseudomonas Infections / blood
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Pseudomonas Infections / drug therapy
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Pseudomonas Infections / microbiology
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Pseudomonas aeruginosa / isolation & purification
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Rabbits
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Serratia Infections / blood*
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Serratia Infections / drug therapy
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Serratia Infections / microbiology
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Serratia marcescens / isolation & purification
Substances
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Pefloxacin
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Ciprofloxacin
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Ceftazidime