Abstract
Three new, seco-ent-kaurane diterpenoids, laxiflorins A, B and C, together with four known diterpenoids eriocalyxin B, oriodonin, and maeocrystals A and B, were isolated from the leaves of Isodon eriocalyx var. laxiflora. Their structures were assigned by a combination of one- and two-dimensional NMR techniques and computer modeling calculations. Laxiflorin C displayed weak cytotoxic activity.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Antineoplastic Agents / chemistry*
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / toxicity*
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Astrocytoma
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Breast Neoplasms
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Cell Line
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Cell Survival / drug effects*
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China
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / toxicity*
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Drug Screening Assays, Antitumor
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Humans
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KB Cells
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Lung Neoplasms
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Magnetic Resonance Spectroscopy
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Male
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Models, Molecular
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Molecular Structure
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Plants, Medicinal*
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Prostatic Neoplasms
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Structure-Activity Relationship
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Tumor Cells, Cultured
Substances
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Antineoplastic Agents
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Diterpenes
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eriocalyxin B