Vigabatrin monotherapy in resistant neonatal seizures

Seizure. 1995 Mar;4(1):57-9. doi: 10.1016/s1059-1311(05)80080-9.

Abstract

Seizures in a term infant with Ohtahara syndrome, associated with polymicrogyria, and a pre-term neonate with similar clinical features, failed to respond to conventional anticonvulsants, but were controlled with vigabatrin monotherapy. Another infant with Aicardi syndrome improved with vigabatrin. Autopsy in the first infant showed no evidence of intramyelinic oedema. The developmental outcome in the two survivors was better than expected for their condition.

Publication types

  • Case Reports

MeSH terms

  • Agenesis of Corpus Callosum
  • Anticonvulsants / administration & dosage*
  • Anticonvulsants / adverse effects
  • Atrophy
  • Brain / abnormalities*
  • Cerebral Cortex / abnormalities
  • Cerebral Cortex / pathology
  • Dose-Response Relationship, Drug
  • Drug Administration Schedule
  • Electroencephalography / drug effects
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature, Diseases / diagnosis
  • Infant, Premature, Diseases / drug therapy*
  • Male
  • Recurrence
  • Spasms, Infantile / diagnosis
  • Spasms, Infantile / drug therapy*
  • Syndrome
  • Vigabatrin
  • gamma-Aminobutyric Acid / administration & dosage
  • gamma-Aminobutyric Acid / adverse effects
  • gamma-Aminobutyric Acid / analogs & derivatives*

Substances

  • Anticonvulsants
  • gamma-Aminobutyric Acid
  • Vigabatrin