Abstract
In vivo [31P]magnetic resonance spectroscopic imaging ([31P]MRSI) was performed on 12 unmedicated, euthymic bipolar patients and 14 control subjects to determine if there were alterations in high-energy P metabolism in the temporal lobes of bipolar patients. Compared with the control group, the patients with bipolar disorder demonstrated significantly lower phosphomonoesters (PME) in both the left and right temporal lobes. No other group differences in P metabolites or lateralized asymmetries were noted. This preliminary study provides support for altered temporal lobe phospholipid metabolism in bipolar disorder.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenosine Triphosphate / metabolism
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Adult
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Bipolar Disorder / diagnosis
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Bipolar Disorder / physiopathology*
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Bipolar Disorder / psychology
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Dominance, Cerebral / physiology
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Female
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Humans
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Magnetic Resonance Imaging
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Magnetic Resonance Spectroscopy*
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Male
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Middle Aged
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Organophosphates / metabolism*
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Personality Assessment
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Phosphates / metabolism
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Phosphocreatine / metabolism
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Reference Values
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Temporal Lobe / physiopathology*
Substances
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Organophosphates
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Phosphates
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Phosphocreatine
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Adenosine Triphosphate