Abstract
Conventional treatment for medulloblastoma includes surgical resection followed by craniospinal irradiation, with the potential risk of subsequent radiotherapy-induced secondary neoplasms. We report a 23-year-old woman previously irradiated nine years earlier for a cerebellar medulloblastoma who developed a new enhancing lesion in the primary radiation field four weeks following completion of high dose chemotherapy with bone marrow transplantation for recurrent disease. Resection of this lesion revealed a low grade glioma with no evidence of recurrent medulloblastoma.
MeSH terms
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Adult
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Astrocytoma / pathology*
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Cerebellar Neoplasms / drug therapy
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Cerebellar Neoplasms / pathology
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Cerebellar Neoplasms / radiotherapy*
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Cerebellum / drug effects
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Cerebellum / pathology
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Cerebellum / radiation effects
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Cranial Irradiation*
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Female
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Follow-Up Studies
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Humans
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Magnetic Resonance Imaging
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Medulloblastoma / drug therapy
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Medulloblastoma / pathology
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Medulloblastoma / radiotherapy*
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Neoplasm Recurrence, Local / drug therapy
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Neoplasm Recurrence, Local / pathology
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Neoplasm Recurrence, Local / radiotherapy
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Neoplasms, Multiple Primary / pathology*
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Neoplasms, Radiation-Induced / pathology*
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Radiotherapy, Adjuvant