3q aberration and monosomy 7 in ANLL presenting with high platelet count and diabetes insipidus

R La Starza; D Falzetti; C Fania; A Tabilio; M F Martelli; C Mecucci

3q aberration and monosomy 7 in ANLL presenting with high platelet count and diabetes insipidus

Haematologica. 1994 Jul-Aug;79(4):356-9.

Authors

R La Starza¹, D Falzetti, C Fania, A Tabilio, M F Martelli, C Mecucci

Affiliation

¹ Ematologia ed Immunologia Clinica, Università degli Studi di Perugia, Italy.

PMID: 7806090

Abstract

Diabetes insipidus and thrombocytosis were presenting symptoms in a case of adult ANLL-M1. Cytogenetic investigations revealed a typical 3q rearrangement, i.e. inv(3)(q21q26). A subclone with monosomy 7 was also found and documented by FISH analysis. Correlations between clinical/hematological features and cytogenetic/FISH results are discussed.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Chromosome Aberrations*
Chromosomes, Human, Pair 3*
Diabetes Insipidus / blood
Diabetes Insipidus / complications
Diabetes Insipidus / genetics*
Humans
Leukemia, Myeloid, Acute / blood
Leukemia, Myeloid, Acute / complications
Leukemia, Myeloid, Acute / genetics*
Male
Middle Aged
Monosomy*
Platelet Count