Comparison of Cryptosporidium parvum and Cryptosporidium wrairi by reactivity with monoclonal antibodies and ability to infect severe combined immunodeficient mice

Infect Immun. 1995 Jan;63(1):360-2. doi: 10.1128/iai.63.1.360-362.1995.

Abstract

Twenty-three monoclonal antibodies raised to Cryptosporidium parvum and 12 raised to C. wrairi reacted with equal intensity with the heterologous species. Despite demonstration of a close immunologic relationship between these two species, C. wrairi did not induce persistent infection in severe combined immunodeficient mice as did C. parvum.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal
  • Antibodies, Protozoan / immunology*
  • Cross Reactions
  • Cryptosporidiosis / immunology
  • Cryptosporidium / immunology*
  • Cryptosporidium / pathogenicity*
  • Cryptosporidium parvum / immunology
  • Cryptosporidium parvum / pathogenicity
  • Female
  • Mice
  • Mice, SCID

Substances

  • Antibodies, Monoclonal
  • Antibodies, Protozoan