An isolated bowel segment (IBS) was created in rats and dogs by a two-stage procedure. Initial coaptation of the bowel segment to the omentum ("omentoenteropexy") is followed by division of its mesentery several weeks later. The viability of the segment is maintained by angiogenesis at the coaptation site. Neoformed blood vessels were shown by angiographic studies, and in a dog the IBS was used for esophageal interposition.