Phylogenetic analysis of the rpoB gene from the plastid-like DNA of Plasmodium falciparum

Mol Biochem Parasitol. 1994 Aug;66(2):221-31. doi: 10.1016/0166-6851(94)90149-x.

Abstract

Malaria and other Apicomplexan parasites harbour two extrachromosomal DNAs. One is mitochondrial and the other is a 35-kb circle with some plastid-like features but whose provenance and function is unknown. In addition to genes for rRNAs, tRNAs and ribosomal proteins, the 35-kb circular DNA of Plasmodium falciparum carries an rpoBC operon which encodes subunits of a eubacteria-like RNA polymerase. The phylogenetic analysis of the complete rpoB sequence presented here supports our inference that the 35-kb circle is the remnant of a plastid genome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Codon / genetics
  • DNA Primers / genetics
  • DNA, Circular / genetics
  • DNA, Protozoan / genetics*
  • DNA-Directed RNA Polymerases / genetics
  • Extrachromosomal Inheritance
  • Genes, Protozoan*
  • Molecular Sequence Data
  • Phylogeny
  • Plasmodium falciparum / enzymology
  • Plasmodium falciparum / genetics*
  • Plastids / genetics
  • Sequence Homology, Amino Acid
  • Species Specificity

Substances

  • Codon
  • DNA Primers
  • DNA, Circular
  • DNA, Protozoan
  • DNA-Directed RNA Polymerases

Associated data

  • GENBANK/X75544