Abstract
Neuropathological studies show that about 20% of all patients suffering from an acinetic-rigid syndrome can not be given the diagnosis of idiopathic Parkinson's disease. Among these non-idiopathic Parkinson-syndromes the corticobasal degeneration (CBD) can be regarded as a separate disease entity. The pathological findings of moderate predominantly frontal and parietal cerebral atrophy, cortical Pick-cells and specific corticobasal inclusion bodies are considered valuable features which support the diagnosis. The clinical Characteristics of CBD are demonstrated in 3 patients including an acinetic-rigid syndrome, limb apraxia and "alien limb"-syndrome, as well as reflex myoclonus. Eye movement disorders, dementia and other rare symptoms may also be present. Electrophysiological reflex-testing helps to corroborate diagnosis. These findings and a summary which includes the previously published cases of CBD show that CBD in most cases can be diagnosed intra vitam.
Publication types
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Case Reports
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English Abstract
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Review
MeSH terms
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Aged
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Atrophy
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Basal Ganglia / pathology
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Basal Ganglia / physiopathology*
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Basal Ganglia Diseases / diagnosis*
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Basal Ganglia Diseases / pathology
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Basal Ganglia Diseases / physiopathology
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Cerebral Cortex / pathology
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Cerebral Cortex / physiopathology*
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Diagnosis, Differential
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Electroencephalography
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Electromyography
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Female
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Humans
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Inclusion Bodies / pathology
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Magnetic Resonance Imaging
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Male
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Middle Aged
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Muscle Rigidity / diagnosis
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Muscle Rigidity / pathology
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Muscle Rigidity / physiopathology
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Myoclonus / diagnosis
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Myoclonus / pathology
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Myoclonus / physiopathology
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Nerve Degeneration / physiology*
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Neurologic Examination
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Parkinson Disease, Secondary / diagnosis*
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Parkinson Disease, Secondary / pathology
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Parkinson Disease, Secondary / physiopathology
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Reflex, Abnormal / physiology
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Supranuclear Palsy, Progressive / diagnosis
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Supranuclear Palsy, Progressive / pathology
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Supranuclear Palsy, Progressive / physiopathology