Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent

S V Joag; E B Stephens; D Galbreath; G W Zhu; Z Li; L Foresman; L J Zhao; D M Pinson; O Narayan

doi:10.1128/JVI.69.2.1367-1369.1995

Simian immunodeficiency virus SIVmac chimeric virus whose env gene was derived from SIV-encephalitic brain is macrophage-tropic but not neurovirulent

J Virol. 1995 Feb;69(2):1367-9. doi: 10.1128/JVI.69.2.1367-1369.1995.

Authors

S V Joag¹, E B Stephens, D Galbreath, G W Zhu, Z Li, L Foresman, L J Zhao, D M Pinson, O Narayan

Affiliation

¹ Marion Merrell Dow Laboratory of Viral Pathogenesis, Department of Microbiology, University of Kansas Medical Center, Kansas City 66160-7424.

Abstract

We inoculated four rhesus macaques with molecularly cloned simian immunodeficiency virus SIVmac239/17E env, a chimeric virus whose env gene was derived from the brain of an SIV-encephalitic macaque. Blood and lymphoid tissues had high frequencies of infected cells. The virus was neuroinvasive, but productive virus replication did not occur in the brain, and animals did not develop encephalitis.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Animals
Brain / virology*
CD4 Lymphocyte Count
Chimera
Encephalitis / virology*
Gene Products, gag / analysis
Genes, env*
Macaca mulatta
Macrophages / virology*
Simian Immunodeficiency Virus / genetics
Simian Immunodeficiency Virus / pathogenicity*
Virulence

Substances

Gag protein p27, Simian immunodeficiency virus
Gene Products, gag

Abstract

Publication types

MeSH terms

Substances

Grants and funding