A cross-sectional study was performed at a plant in which 99 workers were employed in the manufacture of oriented strand board. This group was compared with 165 unexposed workers from the petroleum industry. Both groups were assessed, using a questionnaire, spirometry, and skin prick tests to common environmental antigens. Environmental studies showed a low dust level of 0.27 mg/m3, consisting of particles of a mass median aerodynamic equivalent diameter of 2.5 microns. There were variable concentrations of formaldehyde, up to 0.27 ppm. A significant difference between the oriented strand board workers and oil field workers was noted for the forced expiratory volume in 1 s/forced vital capacity ratio, without significant differences in either the forced expiratory volume in 1 s or the forced vital capacity. Oriented strand board workers who were current smokers were three times as likely to have a forced expiratory volume in 1 s/forced vital capacity ratio of less than 75% of that found in the currently smoking oil field workers. Significant reductions in forced expiratory volume in 1 s (p = .044) and forced vital capacity (p = .022) in oriented strand board workers were noted across the work shift. The oriented strand board workers complained of self-reported asthma and of lower respiratory tract symptoms significantly more frequently than did oil workers for all of the symptoms examined. The prevalence of atopy was not different in the two groups. Lung function was significantly better in oriented strand board workers who had no symptoms, compared with oriented strand board workers who were symptomatic.(ABSTRACT TRUNCATED AT 250 WORDS)