IFN-gamma-stimulated human vascular endothelial cells function as accessory cells for superantigen-induced TNF production in human T cells

Int Arch Allergy Immunol. 1995 Feb;106(2):163-5. doi: 10.1159/000236838.

Abstract

In the presence of IFN-gamma-stimulated vascular endothelial cells which have acquired HLA class II molecules, T cells produced tumor necrosis factors (TNF-alpha and TNF-beta) and IL-2 in response to stimulation with streptococcal pyrogenic exotoxin A.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigen-Presenting Cells / physiology*
  • Bacterial Proteins*
  • Cytokines / biosynthesis*
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / physiology*
  • Exotoxins / immunology
  • HLA-DR Antigens / analysis
  • Humans
  • Interferon-gamma / pharmacology*
  • Interleukin-2 / biosynthesis
  • Lymphotoxin-alpha / biosynthesis
  • Membrane Proteins*
  • Streptococcus pyogenes / immunology*
  • Superantigens / immunology*
  • T-Lymphocytes / metabolism*
  • Tumor Necrosis Factor-alpha / biosynthesis

Substances

  • Bacterial Proteins
  • Cytokines
  • Exotoxins
  • HLA-DR Antigens
  • Interleukin-2
  • Lymphotoxin-alpha
  • Membrane Proteins
  • SpeA protein, Streptococcus pyogenes
  • Superantigens
  • Tumor Necrosis Factor-alpha
  • erythrogenic toxin
  • Interferon-gamma