Abstract
A model of the pathogenesis of insulin-dependent diabetes mellitus, i.e. the initial phase of beta-cell destruction, is proposed: in a cascade-like fashion efficient antigen presentation, unbalanced cytokine, secretion and poor beta-cell defence result in beta-cell destruction by toxic free radicals (O2- and nitric oxide) produced by the beta cells themselves. This entire process is under polygenetic control.
Publication types
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Biography
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Historical Article
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Portrait
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Review
MeSH terms
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Animals
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Awards and Prizes*
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Denmark
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Diabetes Mellitus* / history
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Diabetes Mellitus, Type 1 / etiology
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Diabetes Mellitus, Type 1 / physiopathology*
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Europe
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History, 20th Century
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Humans
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Interleukin-1 / physiology
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Islets of Langerhans / pathology*
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Islets of Langerhans / physiopathology
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Islets of Langerhans / ultrastructure
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Models, Biological
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Nitric Oxide / toxicity
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Receptors, Interleukin-1 / physiology
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Societies, Medical
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Superoxides / toxicity
Substances
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Interleukin-1
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Receptors, Interleukin-1
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Superoxides
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Nitric Oxide