Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats

M Shingu; S Takahashi; M Ito; N Hamamatu; Y Suenaga; Y Ichibangase; M Nobunaga

doi:10.1007/BF00300251

Anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis in rats

Rheumatol Int. 1994;14(2):77-81. doi: 10.1007/BF00300251.

Authors

M Shingu¹, S Takahashi, M Ito, N Hamamatu, Y Suenaga, Y Ichibangase, M Nobunaga

Affiliation

¹ Department of Clinical Immunology, Kyushu University, Beppu, Japan.

PMID: 7824839
DOI: 10.1007/BF00300251

Abstract

The anti-inflammatory effects of recombinant human manganese superoxide dismutase on adjuvant arthritis was investigated. Local application of this manganese superoxide dismutase given every 2 days not only significantly reduced foot swelling but also retarded radiological bone destruction in adjuvant arthritis. Copper zinc superoxide dismutase had little effect on foot swelling.

Publication types

Comparative Study

MeSH terms

Animals
Anti-Inflammatory Agents, Non-Steroidal / administration & dosage*
Arthritis, Experimental / drug therapy*
Half-Life
Humans
Injections, Intra-Articular
Male
Rats
Rats, Inbred Lew
Recombinant Proteins
Superoxide Dismutase / administration & dosage*
Treatment Outcome

Substances

Anti-Inflammatory Agents, Non-Steroidal
Recombinant Proteins
Superoxide Dismutase