Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression?

R F Suijkerbuijk; R J Sinke; D E Weghuis; L Roque; A Forus; F Stellink; A Siepman; C van de Kaa; J Soares; A Geurts van Kessel

doi:10.1016/0165-4608(94)90082-5

Amplification of chromosome subregion 12p11.2-p12.1 in a metastasis of an i(12p)-negative seminoma: relationship to tumor progression?

Cancer Genet Cytogenet. 1994 Dec;78(2):145-52. doi: 10.1016/0165-4608(94)90082-5.

Authors

R F Suijkerbuijk¹, R J Sinke, D E Weghuis, L Roque, A Forus, F Stellink, A Siepman, C van de Kaa, J Soares, A Geurts van Kessel

Affiliation

¹ Department of Human Genetics, University Hospital Nijmegen, The Netherlands.

PMID: 7828145
DOI: 10.1016/0165-4608(94)90082-5

Abstract

Cytogenetic analysis of a metastasis of a human testicular germ cell tumor (seminoma) revealed multiple numerical and structural anomalies, including an abnormally banding region (ABR) present on the short arm of one of the chromosome 12 homologs. Fluorescence in situ- and comparative genomic hybridization experiments revealed that the ABR results from the amplification of 12p11.2-p12.1 derived sequences. We speculate that this particular region may harbor gene(s) relevant for testicular germ cell tumor progression.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Chromosome Aberrations*
Chromosomes, Human, Pair 12*
DNA, Neoplasm / analysis
Gene Amplification*
Humans
In Situ Hybridization, Fluorescence
Male
Seminoma / genetics*
Seminoma / secondary
Testicular Neoplasms / genetics*
Testicular Neoplasms / pathology

Substances

DNA, Neoplasm