Abstract
Forty-four children infected through vertical transmission, from a total of 146 born to HIV-positive mothers, were studied. Immunological data were analysed and compared with those of the noninfected children. Two transmission patterns emerge from the clinical and immunological characteristics: (i) infants infected during pregnancy with severe immunodeficiency and clinical manifestations before the age of 1 year, and (ii) children probably infected perinatally, who have better clinical outcome. Immunological data are important for prognosis and early therapeutic protocols to be established.
MeSH terms
-
CD4-Positive T-Lymphocytes / immunology
-
Case-Control Studies
-
Child, Preschool
-
Female
-
HIV Antibodies / blood
-
HIV Antibodies / immunology
-
HIV Seropositivity / immunology*
-
HIV Seropositivity / transmission
-
Humans
-
Immunoglobulin A / blood
-
Immunoglobulin A / immunology
-
Immunoglobulin G / blood
-
Immunoglobulin G / immunology
-
Immunoglobulin M / blood
-
Immunoglobulin M / immunology
-
Infant
-
Infectious Disease Transmission, Vertical
-
Interferon-gamma / blood
-
Interferon-gamma / immunology
-
Interleukin-1 / blood
-
Interleukin-1 / immunology
-
Interleukin-2 / blood
-
Interleukin-2 / immunology
-
Mothers
-
Prognosis
-
Severity of Illness Index
Substances
-
HIV Antibodies
-
Immunoglobulin A
-
Immunoglobulin G
-
Immunoglobulin M
-
Interleukin-1
-
Interleukin-2
-
Interferon-gamma