Abstract
A 28-year-old woman developed hirsutism, facial edema and clitoromegaly after self-injection of long-acting synthetic androgens. The symptoms were ameliorated by administration of flutamide with a combination oral contraceptive. Flutamide appears to be useful in preventing sequelae of acute androgen excess in women and may be a rational therapy for chronic treatment of androgen excess in women.
MeSH terms
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Adult
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Clitoris / drug effects*
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Edema / chemically induced
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Edema / drug therapy
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Female
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Flutamide / administration & dosage
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Flutamide / pharmacology
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Flutamide / therapeutic use*
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Hirsutism / chemically induced*
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Hirsutism / drug therapy
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Humans
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Hypertrophy / chemically induced
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Hypertrophy / drug therapy
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Paranoid Disorders / chemically induced*
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Paranoid Disorders / drug therapy
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Testosterone Congeners / adverse effects*
Substances
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Testosterone Congeners
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Flutamide