Between January 1988 and December 1993, 254 cases of systemic mycoses were recorded in Thailand. Between 1988 and 1991, the common mycoses were aspergillosis, candidosis and cryptococcosis. In 1992, cryptococcosis increased to 30 cases with 27 being AIDS related. In 1993, cryptococcosis increased dramatically to 57 cases with 49 AIDS related. Eight cases of penicillosis marneffei occurred in AIDS patients in 1993. Skin manifestations of penicillosis marneffei and histoplasmosis in AIDS usually manifested as molluscum contagiosum-like papulonecrotic lesions. Clinical signs and symptoms could not be differentiated from each other.