Crown-rump length in chromosomally abnormal fetuses at 10 to 13 weeks' gestation

Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):32-5. doi: 10.1016/0002-9378(95)90080-2.

Abstract

Objective: Our purpose was to investigate whether fetuses with aneuploidies demonstrate evidence of growth retardation during the first trimester.

Study design: This was a retrospective, cross-sectional study of singleton pregnancies undergoing fetal karyotyping at 10 to 13 weeks' gestation. Measurements of crown-rump length in 135 chromosomally abnormal fetuses were compared with those in 700 chromosomally normal fetuses.

Results: The median crown-rump length of fetuses with trisomy 18 (n = 32) was significantly reduced. In contrast, in fetuses with trisomy 21 (n = 72), trisomy 13 (n = 11), 47,XXX (n = 6), 47,XXY (n = 6), 45,X (n = 5), and triploidy (n = 3) the crown-rump length was not lower than normal.

Conclusion: At 10 to 13 weeks' gestation fetuses with trisomy 18 are growth retarded, whereas in trisomy 21, trisomy 13, and sex chromosome aneuploidy growth is normal.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Aberrations / pathology*
  • Chromosome Disorders
  • Chromosomes, Human, Pair 13
  • Chromosomes, Human, Pair 18
  • Chromosomes, Human, Pair 21
  • Cross-Sectional Studies
  • Crown-Rump Length*
  • Female
  • Fetus / anatomy & histology*
  • Gestational Age
  • Humans
  • Ploidies
  • Pregnancy
  • Pregnancy Trimester, First
  • Retrospective Studies
  • Trisomy