The mechanisms of regulation of vitamin D metabolism in the kidney

Curr Opin Nephrol Hypertens. 1994 Jan;3(1):59-64. doi: 10.1097/00041552-199401000-00008.

Abstract

Recently, the 24-hydroxylase enzyme of 25-hydroxyvitamin D3 was purified from rat and chick kidney, and its complementary DNA was cloned. The length of the rat 24-hydroxylase gene is about 15 kbp with 12 exons. Cloning of the 24-hydroxylase gene made it possible to examine the mechanism of regulation of vitamin D metabolism at the gene level. Expression of renal 24-hydroxylase mRNA is regulated by a balance of plasma parathyroid hormone and 1 alpha,25-dihydroxyvitamin D3 levels, whereas intestinal 24-hydroxylase mRNA is regulated mainly by plasma 1 alpha,25-dihydroxyvitamin D3. This article reviews recent progress in understanding the molecular aspects of vitamin D metabolism.

Publication types

  • Review

MeSH terms

  • Animals
  • Calcitriol / blood
  • Chickens
  • Cholestanetriol 26-Monooxygenase
  • Cloning, Molecular
  • Cytochrome P-450 Enzyme System / biosynthesis
  • Cytochrome P-450 Enzyme System / genetics
  • Exons
  • Gene Expression
  • Homeostasis
  • Humans
  • Kidney / metabolism*
  • Parathyroid Hormone / blood
  • RNA, Messenger / analysis
  • RNA, Messenger / biosynthesis
  • Rats
  • Steroid Hydroxylases / biosynthesis
  • Steroid Hydroxylases / genetics
  • Steroid Hydroxylases / metabolism
  • Vitamin D / metabolism*
  • Vitamin D3 24-Hydroxylase

Substances

  • Parathyroid Hormone
  • RNA, Messenger
  • Vitamin D
  • Cytochrome P-450 Enzyme System
  • Steroid Hydroxylases
  • CYP27A1 protein, human
  • Cholestanetriol 26-Monooxygenase
  • Vitamin D3 24-Hydroxylase
  • Calcitriol