Abstract
Growth-associated protein (GAP)-43 plays a significant role in nerve regeneration and synaptic remodeling. We examined the profiles of GAP-43 mRNA expression in vestibular efferent neurons after labyrinthectomy in adult rats, and clearly demonstrated that labyrinthectomy increased GAP-43 expression in these neurons. This finding suggests the ability of vestibular efferent nerves to regenerate after nerve injury.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaline Phosphatase / metabolism
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Animals
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Ear, Inner / surgery
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GAP-43 Protein
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Gene Expression Regulation / genetics*
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In Situ Hybridization
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Male
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Membrane Glycoproteins / genetics*
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Nerve Tissue Proteins / genetics*
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Neurofilament Proteins / genetics*
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Neurons, Efferent / cytology
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Neurons, Efferent / physiology*
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RNA, Messenger / biosynthesis
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RNA, Messenger / genetics
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Rats
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Rats, Wistar
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Up-Regulation
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Vestibule, Labyrinth / innervation*
Substances
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GAP-43 Protein
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Membrane Glycoproteins
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Nerve Tissue Proteins
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Neurofilament Proteins
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RNA, Messenger
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Alkaline Phosphatase