Abstract
Effectiveness and acceptance of a 4-week treatment with hypericum extract LI 160 were investigated by 663 private practitioners. The results of the 3250 patients (76% women and 24% men), were recorded using data sheets. The age of the patients ranged from 20 to 90 years (mean 51 years). Of the patients, 49% were mildly depressed, 46% intermediate, and 3% severely depressed. In about 30% of the patients, the situation normalized or improved during the therapy. Undesired drug effects were reported in 79 (2.4%) patients and 48 (1.5%) discontinued the therapy. Most frequently noted side effects were gastrointestinal irritations (0.6%), allergic reactions (0.5%), tiredness (0.4%), and restlessness (0.3%).
Publication types
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Clinical Trial
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Multicenter Study
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Antidepressive Agents / adverse effects
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Antidepressive Agents / therapeutic use*
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Depression / drug therapy*
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Drug Monitoring
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Female
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Humans
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Hypericum
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Male
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Middle Aged
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Patient Dropouts
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Perylene / adverse effects
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Perylene / analogs & derivatives*
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Perylene / therapeutic use
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Plant Extracts / adverse effects
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Plant Extracts / therapeutic use*
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Plants, Medicinal
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Quercetin / adverse effects
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Quercetin / analogs & derivatives*
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Quercetin / therapeutic use
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Risk Factors
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Treatment Outcome
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Xanthenes / adverse effects
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Xanthenes / therapeutic use*
Substances
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Antidepressive Agents
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Plant Extracts
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Xanthenes
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Perylene
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Quercetin