Regulation of translation and cell growth by eIF-4E

N Sonenberg

doi:10.1016/0300-9084(94)90185-6

Regulation of translation and cell growth by eIF-4E

Biochimie. 1994;76(9):839-46. doi: 10.1016/0300-9084(94)90185-6.

Author

N Sonenberg¹

Affiliation

¹ Department of Biochemistry, McGill University, Montreal, Quebec, Canada.

PMID: 7880900
DOI: 10.1016/0300-9084(94)90185-6

Abstract

This review discusses the regulation of a key controlling step in the initiation of protein synthesis, the binding of mRNA to ribosomes. Particular focus is given to the phosphorylation of the cap-binding factor, eIF-4E, and the role of this factor in the regulation of cell growth.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Animals
Cell Division / genetics*
Eukaryotic Initiation Factor-4E
Humans
Peptide Initiation Factors / physiology*
Protein Biosynthesis*

Substances

Eukaryotic Initiation Factor-4E
Peptide Initiation Factors