Abstract
6-Amino-6-deoxyascorbic acid was found to inhibit human tumor cell growth. The antitumor effect depends on the tumor type and concentration of the acid. After cell treatment with 6-amino-6-deoxyascorbic acid, drastic morphological changes were found. Although image analysis did not show a difference in p53 and c-myc gene expression, the appearance of chromatin aggregation and DNA fragmentation points to apoptosis or programmed cell death.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / pharmacology*
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Apoptosis / drug effects*
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Ascorbic Acid / analogs & derivatives*
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Ascorbic Acid / pharmacology
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DNA / metabolism
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Humans
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Neoplasms / pathology*
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Proto-Oncogene Proteins c-myc / analysis
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Tumor Cells, Cultured
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Tumor Suppressor Protein p53 / analysis
Substances
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6-amino-6-deoxyascorbic acid
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Antineoplastic Agents
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Proto-Oncogene Proteins c-myc
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Tumor Suppressor Protein p53
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DNA
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Ascorbic Acid