Abstract
We describe the molecular cloning of a serogroup 2 simian retrovirus (SRV; D2/RHE/OR) and present the sequence of its envelope (env) glycoprotein gene and 3' long terminal repeat region. This report documents the first infectious molecular clone of a serogroup 2 SRV and provides env sequence verification of genetic diversity among serogroup 2 SRV isolates.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Cell Line
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Cloning, Molecular
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DNA, Viral
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Gene Products, env / genetics*
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Molecular Sequence Data
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Repetitive Sequences, Nucleic Acid*
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Retroviruses, Simian / classification
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Retroviruses, Simian / genetics*
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Retroviruses, Simian / pathogenicity
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Retroviruses, Simian / physiology
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Sequence Homology, Amino Acid
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Sequence Homology, Nucleic Acid
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Serotyping
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Simian Acquired Immunodeficiency Syndrome / virology*
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Transfection
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Virulence / genetics
Substances
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DNA, Viral
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Gene Products, env