Some fibrinolytic parameters (euglobulin clot lysis time, activities and antigens of tissue plasminogen activator and inhibitor), serum lipids and their mutual relations were studied in 31 patients with nephrotic syndrome. Euglobulin clot lysis time was found to be significantly prolonged in patients with nephrotic syndrome when compared to control group. Activity and antigen of tissue plasminogen activator were significantly higher in healthy volunteers, whereas nephrotic patients activity of tissue plasminogen activator inhibitor was significantly higher than in controls. Cholesterol, LDL and VLDL were elevated in patients with nephrotic syndrome when compared to controls. LDL was found to be positively related to both tissue plasminogen activity and antigen in nephrotic patients. Serum cholesterol correlated positively with albuminemia in these patients.