Sneddon's syndrome: clinical and immunohistochemical findings

Clin Neurol Neurosurg. 1994 Nov;96(4):310-3. doi: 10.1016/0303-8467(94)90120-1.

Abstract

Results of immunological studies on skin biopsies of 5 patients with Sneddon's syndrome are reported. Also studied were coagulation factors and autoantibodies believed to play a role in this syndrome. Hemostasis was normal except for a mild increase of fibrinogen in one subject; lupus anticoagulant (LAC) and anticardiolipin antibodies were negative in all. The skin biopsies ruled out systemic vasculitis and vasculitis in association with connective tissue diseases. Sneddon's syndrome is a peculiar clinicopathological condition, probably with several etiologies, but is distinct from primary antiphospholipid syndrome.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Aged
  • Antibodies, Anticardiolipin / analysis
  • Antiphospholipid Syndrome / genetics
  • Antiphospholipid Syndrome / immunology
  • Antiphospholipid Syndrome / pathology
  • Autoantibodies / analysis*
  • Biopsy
  • Blood Coagulation Factors / analysis*
  • Brain Ischemia / genetics
  • Brain Ischemia / immunology
  • Brain Ischemia / pathology*
  • Diagnosis, Differential
  • Female
  • Humans
  • Lupus Coagulation Inhibitor / analysis
  • Middle Aged
  • Skin / immunology
  • Skin / pathology*
  • Skin Diseases, Vascular / genetics
  • Skin Diseases, Vascular / immunology
  • Skin Diseases, Vascular / pathology*

Substances

  • Antibodies, Anticardiolipin
  • Autoantibodies
  • Blood Coagulation Factors
  • Lupus Coagulation Inhibitor