Abstract
The aim of this study was to examine the subgingival microflora associated with failing implants, and to determine their susceptibility to commonly used antibiotics in periodontal therapy and dental practice. Thirteen partially edentulous patients with 19 failing implants were selected. Clinical examination included probing depth, attachment level, gingival index, plaque index, and radiographic analyses. Two subgingival plaque samples were taken from each failing implant and analyzed for microbial composition. Fusobacterium nucleatum, Porphyromonas gingivalis, and Prevotella intermedia were the prevalent cultivable microflora. Antimicrobial susceptibility of isolates was determined by the agar dilution technique. Antibacterial activity of penicillin G, amoxicillin, amoxicillin-clavulanate, and the combination amoxicillin-metronidazole was significantly higher than with other antibiotics tested. These data indicated that the commonly-used antibiotics were highly effective against bacteria isolated around failing implants, which would suggest the use of these antibiotics to control peri-implant infections.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amoxicillin / pharmacology
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Amoxicillin-Potassium Clavulanate Combination
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Anti-Bacterial Agents / pharmacology*
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Anti-Bacterial Agents / therapeutic use
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Bacteria, Anaerobic / drug effects*
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Bacteria, Anaerobic / isolation & purification
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Clavulanic Acids / pharmacology
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Dental Implants / adverse effects
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Dental Implants / microbiology*
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Dental Plaque / microbiology
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Dental Plaque Index
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Drug Combinations
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Fusobacterium nucleatum / drug effects
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Fusobacterium nucleatum / isolation & purification
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Humans
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Metronidazole / administration & dosage
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Metronidazole / pharmacology
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Microbial Sensitivity Tests
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Penicillin G / pharmacology
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Periodontal Index
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Periodontitis / etiology
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Periodontitis / microbiology
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Periodontium / microbiology*
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Porphyromonas gingivalis / drug effects
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Porphyromonas gingivalis / isolation & purification
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Prevotella intermedia / drug effects
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Prevotella intermedia / isolation & purification
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Prosthesis Failure
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Prosthesis-Related Infections / drug therapy*
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Prosthesis-Related Infections / etiology
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Prosthesis-Related Infections / microbiology
Substances
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Anti-Bacterial Agents
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Clavulanic Acids
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Dental Implants
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Drug Combinations
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Metronidazole
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Amoxicillin-Potassium Clavulanate Combination
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Amoxicillin
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Penicillin G