This paper discusses recent trends concerning the commercialization of pesticides in Mexico and focuses on organophosphates and their potential health risk impact. It points out the existing lack of knowledge on health effects associated to chronic exposure to organophosphate pesticides. A need for both toxicological and epidemiologic studies of chronic exposure is identified. Regulatory programs for pesticides in Mexico and the United States are also compared. The paper also addresses the possibility of effective enforcement of environmental and health regulations in Mexico as a result of more rigorous surveillance under NAFTA.