Abstract
2-Amino-5-tert-butyl-2-oxazoline (ATBO, 2) was synthetized from 3,3-dimethyl-2-iodobutyl isocyanate via N-(3,3-dimethyl-2-iodobutyl) urea (1). The structures of compounds 1 and 2 are based on analytical and spectroscopic data. Compound 2 induced in rats and mice a peripheral antinociceptive effect through both spinal and supraspinal mechanisms. ATBO did not impair motor coordination or activity of the experimental animals.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates
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Acetic Acid
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemical synthesis*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology
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Dose-Response Relationship, Drug
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Male
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Methimazole / pharmacology
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Mice
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Morphine / pharmacology
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Motor Activity / drug effects
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Naloxone / pharmacology
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Oxazoles / chemical synthesis*
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Oxazoles / pharmacology
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Pain / chemically induced
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Pain / prevention & control
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Pain Measurement / drug effects
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Postural Balance / drug effects
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Rats
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Rats, Wistar
Substances
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2-amino-5-tert-butyl-2-oxazoline
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Acetates
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Anti-Inflammatory Agents, Non-Steroidal
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Oxazoles
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Naloxone
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Methimazole
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Morphine
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Acetic Acid