Ki-1-positive large-cell cutaneous lymphoma mimicking a Stewart-Treves angiosarcoma

Dermatology. 1995;190(1):77-82. doi: 10.1159/000246641.

Abstract

Anaplastic large-cell cutaneous lymphomas (ALCL) represent a heterogeneous group. Primitive cutaneous lymphomas are exceptional, sometimes with a deceptive clinical aspect, but must be considered as a distinct clinicopathologic entity. We report a case of a cutaneous ALCL, appearing 7 years after a homolateral Hodgkin ganglionic lymphoma and occurring on a chronic lymphoedema of the arm. A Stewart-Treves angiosarcoma was suggested owing to its location, vascular aspect and low histologic differentiation. Immunohistochemistry was helpful in making the diagnosis of ALCL. Southern blotting analysis revealed a rearrangement of the beta-chain of the T-receptor gene, thus suggesting the T-cell origin of this lymphoma.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Blotting, Southern
  • DNA, Neoplasm / analysis
  • Diagnosis, Differential
  • Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
  • Hemangiosarcoma / diagnosis
  • Hemangiosarcoma / pathology*
  • Humans
  • Immunohistochemistry
  • Immunophenotyping
  • Lymphoma, Large-Cell, Anaplastic / diagnosis
  • Lymphoma, Large-Cell, Anaplastic / immunology
  • Lymphoma, Large-Cell, Anaplastic / pathology*
  • Lymphoma, Large-Cell, Anaplastic / therapy
  • Male
  • Skin Neoplasms / diagnosis
  • Skin Neoplasms / immunology
  • Skin Neoplasms / pathology*
  • Skin Neoplasms / therapy
  • Wrist

Substances

  • DNA, Neoplasm