7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-CoA reductase inhibitors

V Cecchetti; A Fravolini; P G Pagella; O Tabarrini; A Temperini

doi:10.1016/s0968-0896(00)82180-x

7-(Disubstituted thiazolyl)-3,5-dihydroxy-6-heptenoic/heptanoic acid derivatives as HMG-CoA reductase inhibitors

Bioorg Med Chem. 1994 Aug;2(8):799-806. doi: 10.1016/s0968-0896(00)82180-x.

Authors

V Cecchetti¹, A Fravolini, P G Pagella, O Tabarrini, A Temperini

Affiliation

¹ Istituto di Chimica Farmaceutica e Tecnia Farmaceutica, Università di Perugia, Italy.

PMID: 7894974
DOI: 10.1016/s0968-0896(00)82180-x

Abstract

A series of disubstituted thiazoles, functionalized with the essential 3,5-dihydroxy-6-heptenoic or heptanoic chain, were prepared and evaluated for their ability to inhibit the enzyme HMG-CoA reductase in vitro. All the synthesized compounds 46-61 showed a moderate inhibitory potency.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Hydroxymethylglutaryl-CoA Reductase Inhibitors*
In Vitro Techniques
Liver / enzymology
Molecular Structure
Rats
Structure-Activity Relationship
Thiazoles / chemical synthesis
Thiazoles / chemistry
Thiazoles / pharmacology*

Substances

Hydroxymethylglutaryl-CoA Reductase Inhibitors
Thiazoles