Clinical profile, laboratory characteristics and outcome in miliary tuberculosis

QJM. 1995 Jan;88(1):29-37.

Abstract

We report a retrospective series of 100 non-HIV adult patients with miliary tuberculosis (MTB) treated in a tertiary care centre. There were 51 males. Their mean age was 35 years. Predisposing conditions existed in 34. Twelve patients had larger-than-miliary (> 2 mm) shadows in their chest roentgenograms. Five presented with acute respiratory failure, and early treatment cured four of them. Hyponatraemia occurred in 42/60 patients (70%) for whom values were available. Twelve patients (12%) died of MTB. Temperature > or = 39.3 degrees C (p < 0.01), hypoalbuminaemia (p < 0.01), hyponatraemia (p < 0.001), history of vomiting (p < 0.001) and presence of crepitations on auscultation (p < 0.001) were independent predictors of mortality. Diagnosis of MTB is difficult even in an endemic area, as the clinical symptoms are non-specific and the chest roentgenograms do not always reveal classical miliary changes. A high index of clinical suspicion and diligent efforts in confirming the diagnosis are needed, as early therapy yields good results.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Biopsy, Needle
  • Child
  • Developing Countries*
  • Female
  • Humans
  • Liver / microbiology
  • Lung / diagnostic imaging
  • Lymph Nodes / microbiology
  • Male
  • Middle Aged
  • Radiography
  • Retrospective Studies
  • Treatment Outcome
  • Tuberculosis, Miliary / diagnosis*
  • Tuberculosis, Miliary / diagnostic imaging
  • Tuberculosis, Miliary / drug therapy