[Antiphospholipid antibodies: cause of thrombosis or an epiphenomenon?]

Presse Med. 1995 Feb 4;24(5):267-70.
[Article in French]

Abstract

Antiphospholipid antibodies (aPL) present in systemic lupus erythematosus and the primary antiphospholipid syndrome are a well-known risk factor for thrombosis. Most of them require the presence of a cofactor, beta 2-glycoprotein I for anticardiolipin antibodies, prothrombin for lupus anticoagulant. These aPL are of the "immune" type. APL are also found in various non-immunological conditions, in which repeated endothelial or membranous damages appear to be frequent, but thromboses are rare. Most of these aPL are cofactor-independent, except those induced by chlorpromazine, and might belong to "natural" antibodies.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Antibodies, Antiphospholipid / physiology*
  • Disease Models, Animal
  • Humans
  • Risk Factors
  • Thrombosis / immunology*
  • Thrombosis / physiopathology

Substances

  • Antibodies, Antiphospholipid