Abstract
The Th-2 response to microfilariae of Brugia malayi in BALB/c mice is associated with peritoneal eosinophilia. These eosinophils had an activated hypodense phenotype in vivo and expressed high levels of the class II major histocompatibility complex (MHC). Interleukin 4 up-regulated the class II MHC, whereas gamma interferon inhibited class II MHC expression on eosinophils.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Brugia malayi / immunology*
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CD4-Positive T-Lymphocytes / immunology
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Eosinophils / immunology*
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Filariasis / immunology
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Histocompatibility Antigens Class II / metabolism*
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Interferon-gamma / pharmacology
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Interleukin-4 / pharmacology
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Interleukin-5 / pharmacology
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Mice
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Mice, Inbred BALB C
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Microfilariae / immunology
Substances
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Histocompatibility Antigens Class II
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Interleukin-5
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Interleukin-4
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Interferon-gamma