A Macintosh program for result analysis in HLA genotyping by the modified PCR-RFLP method

Biotechniques. 1993 Dec;15(6):1072-5.

Abstract

We describe in this report a computer program for easy interpretation of polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) patterns generated during HLA Class II typing by the modified PCR-RFLP method. HLA-DQA1, HLA-DQB1, HLA-DRB1 and HLA-DPB1 typing result analysis are thus greatly simplified. The program also allows video capture and image storage, which are becoming a new standard in molecular biology laboratories.

MeSH terms

  • Genotype*
  • HLA Antigens / genetics*
  • HLA-DP Antigens / genetics
  • HLA-DP beta-Chains
  • HLA-DQ Antigens / genetics
  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DR Antigens / genetics
  • HLA-DRB1 Chains
  • Histocompatibility Antigens Class II / genetics
  • Humans
  • Polymerase Chain Reaction*
  • Polymorphism, Restriction Fragment Length*
  • Software*

Substances

  • HLA Antigens
  • HLA-DP Antigens
  • HLA-DP beta-Chains
  • HLA-DPB1 antigen
  • HLA-DQ Antigens
  • HLA-DQ alpha-Chains
  • HLA-DQ beta-Chains
  • HLA-DQA1 antigen
  • HLA-DQB1 antigen
  • HLA-DR Antigens
  • HLA-DRB1 Chains
  • Histocompatibility Antigens Class II