Abstract
To assess the stability of IS6110 restriction fragment length polymorphism patterns, DNA fingerprints of 6 Mycobacterium bovis isolates from 1 patient and of 41 Mycobacterium tuberculosis isolates from 18 patients were compared. The fingerprint pattern for a given patient remained identical or nearly identical despite recovery of the isolates during intervals which ranged from 8 months to 4.5 years. Changes in drug resistance profile did not alter a strain's fingerprint pattern.
Publication types
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Comparative Study
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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DNA Fingerprinting
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DNA Transposable Elements / genetics*
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DNA, Bacterial / genetics*
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Drug Resistance, Microbial / genetics
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Genome, Bacterial
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Humans
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Mycobacterium tuberculosis / genetics*
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Mycobacterium tuberculosis / isolation & purification
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Polymorphism, Restriction Fragment Length*
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Species Specificity
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Sputum / microbiology
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Tuberculosis / microbiology*
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Urine / microbiology
Substances
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DNA Transposable Elements
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DNA, Bacterial