Abstract
Commitment to the cell cycle in fission yeast requires the function of the cdc10+ transcriptional activator at START. The product of the cdc18+ gene is a major downstream target of cdc10+, and transcription of cdc18+ is activated by cdc10+ during passage through START. The cdc18+ function is required for entry into S phase. In addition, the product of the cdc18+ gene is part of the checkpoint control that prevents mitosis from occurring until S phase is completed. Thus, cdc18+ plays a key role in coupling S phase to START and mitosis.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Amino Acid Sequence
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Base Sequence
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Cell Cycle / genetics*
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Cell Cycle Proteins*
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Cloning, Molecular
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Fungal Proteins / genetics*
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Fungal Proteins / metabolism
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Gene Deletion
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Genes, Fungal / genetics*
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Mitosis / genetics
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Models, Genetic
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Molecular Sequence Data
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Periodicity
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Phenotype
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S Phase / genetics
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Schizosaccharomyces / genetics*
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Schizosaccharomyces pombe Proteins
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Sequence Homology, Amino Acid
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Suppression, Genetic
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Transcription Factors
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Transcription, Genetic
Substances
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Cell Cycle Proteins
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Fungal Proteins
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Schizosaccharomyces pombe Proteins
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Transcription Factors
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cdc10 protein, S pombe
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cdc18 protein, S pombe
Associated data
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GENBANK/L14569
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GENBANK/L16793
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GENBANK/L19248
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GENBANK/L19249
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GENBANK/L33709
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GENBANK/S60902
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GENBANK/S60903
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GENBANK/S60904
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GENBANK/S60905
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GENBANK/S60924