There were 2,330 lung transplants reported to the St. Louis International Lung Transplant Registry as of September 1, 1993. The most common indication continues to be chronic obstructive pulmonary disease. The 1-, 2-, and 3-year actuarial survival statistics for all transplants were 68%, 59%, and 54%, respectively. Infection was the major cause of both early and late mortality, though in the latter situation, infection most often occurred in a setting of enhanced immunosuppression for chronic rejection.