Abstract
We report the case of a patient with acute myeloid leukemia in second remission who received an allogeneic bone marrow transplant from an immunosuppressed HLA-identical sibling donor. The donor was receiving prednisone, azathioprine and cyclosporine for a cadaveric renal allograft. Bone marrow growth in culture from the donor was normal. Engraftment was within normal limits. Moderate acute graft-versus-host disease (GVHD) developed. We suggest that transplants from immunosuppressed donors are feasible and that this does not preclude the development of GVHD.
MeSH terms
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Antineoplastic Agents / therapeutic use*
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Azathioprine / therapeutic use*
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Bone Marrow / drug effects
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Bone Marrow Cells
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Bone Marrow Transplantation* / immunology
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Cyclosporine / therapeutic use*
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Drug Therapy, Combination
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Family Health
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Female
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Graft vs Host Disease / etiology
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Histocompatibility / immunology
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Humans
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Immunosuppressive Agents / therapeutic use*
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Leukemia, Myeloid / therapy
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Middle Aged
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Prednisone / therapeutic use*
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Time Factors
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Tissue Donors
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Transplantation, Homologous
Substances
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Antineoplastic Agents
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Immunosuppressive Agents
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Cyclosporine
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Azathioprine
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Prednisone