Intrauterine insemination (IUI) has been used for treatment of infertility for many years with discouraging results (8.3% in the analysis of Dorangeon and Quereux). A new approach of IUI, using ovarian stimulation, ovulation monitoring and sperm preparation has significantly improved the results. The obtained pregnancy rate (15 to 25%) are now comparable to those reported with IVF or GIFT. Therefore IUI should be offered to patients with patent tubes prior to their referral for the more invasive procedure FIV or GIFT.