Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties

B Kunze; R Jansen; G Höfle; H Reichenbach

doi:10.7164/antibiotics.47.881

Crocacin, a new electron transport inhibitor from Chondromyces crocatus (myxobacteria). Production, isolation, physico-chemical and biological properties

J Antibiot (Tokyo). 1994 Aug;47(8):881-6. doi: 10.7164/antibiotics.47.881.

Authors

B Kunze¹, R Jansen, G Höfle, H Reichenbach

Affiliation

¹ GBF, Gesellschaft für Biotechnologische Forschung mbH, Braunschweig, FRG.

PMID: 7928674
DOI: 10.7164/antibiotics.47.881

Abstract

Crocacin was isolated from the biomass of the myxobacterium Chondromyces crocatus, strain Cm c3. It inhibited the growth of a few Gram-positive bacteria and a wide spectrum of yeasts and molds. In beef heart submitochondrial particles, crocacin blocked the electron transport within the bc1-segment (complex III) and caused a red shift in the reduced spectrum of cytochrome b with a maximum at 569 nm.

MeSH terms

Anti-Bacterial Agents / biosynthesis
Anti-Bacterial Agents / isolation & purification*
Anti-Bacterial Agents / pharmacology*
Chemical Phenomena
Chemistry, Physical
Electron Transport / drug effects
Fermentation
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Myxococcales / chemistry*
Myxococcales / metabolism*
Polyenes / chemical synthesis
Polyenes / isolation & purification
Polyenes / pharmacology

Substances

Anti-Bacterial Agents
Polyenes
crocacin