Abstract
In addition to huperzinine [1], a new alkaloid, N-demethylhuperzinine [2], was isolated from the aerial parts of Lycopodium casuarinoides by bioassay-directed fractionation. The structure of 2 was established by spectral analysis and extensive nOe difference nmr studies as well as spectral comparison with huperzinine. N-Demethylhuperzinine [2] exhibited anticholinesterase activity in pharmacological studies.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / isolation & purification*
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Alkaloids / pharmacology
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Animals
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Cholinesterase Inhibitors / isolation & purification*
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Cholinesterase Inhibitors / pharmacology
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Drugs, Chinese Herbal / isolation & purification
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Drugs, Chinese Herbal / pharmacology
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Male
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Mice
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Muscles / drug effects
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Muscles / enzymology
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Plants, Medicinal / chemistry*
Substances
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Alkaloids
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Cholinesterase Inhibitors
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Drugs, Chinese Herbal
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N-demethylhuperzinine
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huperzinine