Abstract
The prolactin response to oral d-fenfluramine (30 mg) was measured in nine patients with late-onset Alzheimer's disease and in an elderly comparison group. The serotonin-mediated prolactin response was significantly greater in the patients with Alzheimer's disease than in the comparison group. This finding suggests that central serotonin responsivity is greater in Alzheimer's disease.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Aged, 80 and over
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Alzheimer Disease / blood*
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Alzheimer Disease / diagnosis
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Alzheimer Disease / physiopathology
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Female
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Fenfluramine / pharmacology*
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Geriatric Assessment
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Humans
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Male
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Prolactin / blood*
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Receptors, Serotonin / drug effects
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Receptors, Serotonin / physiology
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Serotonin / physiology*
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Stereoisomerism
Substances
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Receptors, Serotonin
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Fenfluramine
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Serotonin
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Prolactin