Abstract
Eighteen patients with gastric cancer with peritoneal metastasis were treated with methotrexate/5-fluorouracil sequential therapy. In four patients, a partial response was obtained and in another four, symptomatic relief was obtained by the therapy. As side effects, BM suppression was seen in 9 and GI symptoms in 6 patients. Intraaortic, low-dose and 3-hour-interval procedure are recommended in the therapy.
Publication types
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Clinical Trial
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English Abstract
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / secondary*
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Marrow / drug effects
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Drug Administration Schedule
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Female
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Fluorouracil / administration & dosage
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Fluorouracil / adverse effects
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Humans
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Infusions, Intra-Arterial
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Infusions, Intravenous
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Male
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Methotrexate / administration & dosage
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Methotrexate / adverse effects
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Middle Aged
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Peritoneal Neoplasms / drug therapy*
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Peritoneal Neoplasms / secondary*
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Prognosis
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Stomach Neoplasms / pathology*
Substances
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Fluorouracil
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Methotrexate