Screening test for growth hormone deficiency: usefulness of L-dopa-propranolol provocative test

J Paediatr Child Health. 1994 Aug;30(4):328-30. doi: 10.1111/j.1440-1754.1994.tb00656.x.

Abstract

This is a retrospective review of 185 short children who were tested for growth hormone (GH) secretion using the L-dopa-propranolol provocative test. One hundred and thirty-three children were deemed to have passed the screening test when a GH concentration of greater than 15 miu/L was elicited after stimulation. Fifty-two failed the screening test, of which 33 were diagnosed as having growth hormone deficiency (GHD) when they had inadequate growth hormone response to insulin-induced hypoglycaemia. The other 19 were low-responders since they showed adequate GH response to insulin tolerance test (ITT). The low-responder rate to L-dopa-propranolol provocative test among short children who are not GH deficient was 12.5%. The low cost of L-dopa and propranolol, the simplicity and safety of the test, and the acceptable rate of low-responders make the test an effective screening test for GHD.

MeSH terms

  • Adolescent
  • Child
  • Child, Preschool
  • Female
  • Growth Disorders / diagnosis*
  • Growth Disorders / physiopathology
  • Growth Hormone / deficiency*
  • Growth Hormone / metabolism
  • Humans
  • Infant
  • Levodopa* / adverse effects
  • Male
  • Mass Screening
  • Propranolol* / adverse effects
  • Retrospective Studies

Substances

  • Levodopa
  • Growth Hormone
  • Propranolol