Abstract
A receptor tyrosine kinase/Ras signaling pathway controls the specification of vulval cell fates in Caenorhabditis elegans. Recently, C. elegans genes encoding proteins with similarity to mammalian Raf (lin-45), mitogen-activated protein kinase (mpk-1/sur-1), and an HNF-3 transcription factor (lin-31) have been identified and shown to act downstream of let-60 (ras) in this pathway. These genetically identified gene products bridge the gap between signal transduction at the plasma membrane and the control of cell fate specification in the nucleus.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Caenorhabditis elegans / embryology*
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Caenorhabditis elegans / genetics
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Caenorhabditis elegans Proteins*
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Calcium-Calmodulin-Dependent Protein Kinases / metabolism
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DNA-Binding Proteins / metabolism
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Embryo, Nonmammalian / physiology
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Embryonic Induction / genetics
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Female
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Gene Expression Regulation, Developmental*
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Genes, Helminth
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Genes, ras
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Helminth Proteins / genetics
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Helminth Proteins / metabolism*
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Larva
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Membrane Proteins / metabolism
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Mitogen-Activated Protein Kinase 1
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Morphogenesis / genetics
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Protein Serine-Threonine Kinases / metabolism
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Receptor Protein-Tyrosine Kinases / metabolism
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Receptors, Notch
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Signal Transduction*
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Transcription Factors / metabolism
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Vulva / cytology
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Vulva / embryology*
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ras Proteins / metabolism
Substances
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Caenorhabditis elegans Proteins
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DNA-Binding Proteins
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Helminth Proteins
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Lin-12 protein, C elegans
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Membrane Proteins
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Receptors, Notch
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Transcription Factors
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lin-31 protein, C elegans
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let-60 protein, C elegans
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Receptor Protein-Tyrosine Kinases
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Protein Serine-Threonine Kinases
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Calcium-Calmodulin-Dependent Protein Kinases
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Mitogen-Activated Protein Kinase 1
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mpk-1 protein, C elegans
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ras Proteins