Abstract
The lin-12/Notch proteins appear to act as transmembrane receptors for intercellular signals that specify cell fates during animal development. Recent structure/function studies have shown that the lin-12/Notch intracellular domain alone has the intrinsic signal-transducing activity of the intact protein, and that the role of the extracellular domain is to regulate this intrinsic activity. These studies have also suggested that the different lin-12/Notch proteins in a given organism are interchangeable biochemically and have addressed the role of lin-12/Notch genes in development.
MeSH terms
-
Amino Acid Sequence
-
Animals
-
Ankyrin Repeat
-
Caenorhabditis elegans / embryology
-
Caenorhabditis elegans / genetics
-
Caenorhabditis elegans Proteins*
-
Drosophila / embryology
-
Drosophila / genetics
-
Drosophila Proteins
-
Embryonic Induction / genetics*
-
Gene Expression Regulation, Developmental*
-
Helminth Proteins / chemistry
-
Helminth Proteins / physiology
-
Humans
-
Insect Hormones / chemistry
-
Insect Hormones / physiology*
-
Membrane Proteins / chemistry
-
Membrane Proteins / physiology*
-
Multigene Family
-
Receptors, Notch
-
Signal Transduction / physiology*
-
Structure-Activity Relationship
Substances
-
Caenorhabditis elegans Proteins
-
Drosophila Proteins
-
Helminth Proteins
-
Insect Hormones
-
Lin-12 protein, C elegans
-
Membrane Proteins
-
N protein, Drosophila
-
Receptors, Notch